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Leptin, an important regulator of mesenchymal differentiation, has a significantly stronger effect of promoting osteogenesis and inhibiting adipogenesis in bmMSCs than in cbMSCs. Here, it is shown that neither Fas TMD membrane organization nor its conformation is affected by ceramide. The normal and hypothyroid groups showed a wider periodontal ligament at the bucco-distal site at sildenafil coupons the coronal level, while the hyperthyroid group showed a widening which was not spatially oriented.
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